Patients with SLE usually require a kidney puncture. SLE is an autoimmune disease, which can lead to multiple organ and system involvement, with too many differences in performance. Among the involved organs, it is often accompanied by kidney damage, ranging from mild to severe, or clinically insidious or with problems such as protein occult blood, which can even involve kidney function, and finally serious cases can develop renal insufficiency, endangering the lives of patients. Those who have the condition should go for early kidney puncture to clarify the pathological type of kidney damage, timely and early standardized management, determine the treatment plan, especially the amount of hormone therapy options, and at the same time can determine the patient’s prognosis.