SLE is an autoimmune disease with multiple autoantibodies in the body, which requires long-term treatment. What are the common clinical manifestations of SLE 1. systemic symptoms: fever, malaise, weight loss, etc. 2. skin and mucous membrane: 80% of patients have rashes during the course of the disease, the most characteristic ones are butterfly-shaped erythema on the cheeks, discoid erythema, frostbite like rash, perineal erythema, allergic dermatitis after sun exposure, recent massive hair loss, painless ulcers in the oral and nasal mucous membranes, reticulocutaneous cyanosis, fingers appearing when cold or emotionally excited pale, purple, numbness. 3.Arthralgia, muscle pain, muscle weakness. 4. Pleural effusion, pericardial effusion. 5. Lupus nephritis: protein, red blood cells or tubular type in urine, abnormal renal function, renal hypertension. 6.Blood routine: leukocyte and platelet reduction, hemolytic anemia. 7.Lung: lupus pneumonia, interstitial lung lesions, pulmonary hypertension, alveolar hemorrhage. 8, heart: myocardial damage, heart valve disease, arrhythmia, heart failure, may have chest tightness, anterior heart area discomfort symptoms. 9.Nervous system: headache, hemiparesis, epilepsy, hallucinations, delusions, impaired consciousness, paraplegia, numbness of limbs, etc. 10, digestive system: loss of appetite, vomiting, abdominal pain, diarrhea, ascites, elevated transaminases, but also acute pancreatitis, pseudo-intestinal obstruction, intestinal necrosis and other acute abdominal symptoms. 11. Antiphospholipid syndrome: arteriovenous thrombosis, spontaneous abortion, pulmonary embolism, cerebral infarction. What are the specific laboratory tests for SLE Anti-nuclear antibodies, anti-dsDNA, anti-Sm are of high diagnostic value for SLE. Anti-rRNP, anti-SSA, anti-SSB, anti-histone antibodies, as well as anti-cardiolipin antibodies, anti-β2-GP1 and other antiphospholipid antibodies can also be present; reduced complement is beneficial to the diagnosis of SLE and can reflect the activity of the disease. How to treat SLE 1.Glucocorticoids: The use of hormones during the active stage of the disease can accelerate the remission of the disease, and can be gradually reduced to the minimum maintenance dose after the disease is stabilized; for critical SLE, hormone shock therapy is required. 2, hydroxychloroquine and immunosuppressants: combined with hormones, can better control SLE activity, facilitate hormone reduction, and prevent relapse of the disease. 3.Other: high-dose gammaglobulin: suitable for those with severe disease and weak constitution or (and) serious infection; biological agents: the most commonly used is anti-CD20 monoclonal antibody, which is suitable for stubborn disease and the above drugs are not effective; plasma exchange, immunosorbent, etc. Can SLE marry and have children? The disease remission is stable for more than 1 year, the maintenance amount of prednisone is less than 15mg/day, stop using cytotoxic drugs such as cyclophosphamide, methotrexate, morte-macrolimus, etc. for more than 6 months, and leflunomide is best to stop for more than 2 years, no important organ lesions, pregnancy can be considered. SLE activity should be closely monitored during pregnancy, regular follow-up, and early hospitalization is required in the perinatal period. What are the daily precautions for SLE 1, maintain a positive and optimistic attitude and happy mood, establish confidence to overcome the disease; pay attention to rest, avoid strain and mental tension, and actively prevent and control infection; do not smoke, drink alcohol. 2, pay attention to sun protection, avoid ultraviolet radiation; pay attention to contraception, should not use estrogen-containing contraceptives; try not to use cosmetics containing chemical ingredients, do not dye hair, eyebrow tattoo. 3. Diet: low salt, low fat, light and easy to digest. When you have solar dermatitis, you should not eat photosensitive foods such as shiitake mushrooms, cilantro and celery; avoid eating hot foods such as mutton, dog meat, donkey meat, cinnamon, chili, raw onion, raw garlic, leek, etc., eat less seafood, forbid eating royal jelly, ginseng, ganoderma lucidum, cordyceps and other health care products, supplement meat, eggs, milk and other high-quality proteins when you have lupus nephritis with large amount of proteinuria; eat more foods rich in vitamin C and high calcium.