After applying acyclovir ointment local skin variation if the drug stimulation caused by, can be appropriate to reduce the dose of drugs, if it is the original disease and triggered by secondary symptoms, there is no need to adjust the medication. 1. Drug stimulation: Acyclovir cream in the presence of antiviral drug components, for the skin surface there will be a certain degree of irritation, belonging to the routine use of drugs caused by adverse reactions. If the skin of the local application site is tight or hard after using acyclovir ointment, the dose of the drug can be appropriately reduced to effectively alleviate the adverse phenomenon, which will gradually dissipate on its own and will not cause direct damage to the skin. 2. Secondary symptoms of pre-existing diseases: Acyclovir ointment is generally used for viral infections on the skin surface. When the virus infecting the surface of the skin is aggravated or causes local skin damage, it may also lead to hardening or loss of elasticity of the diseased skin area, which is a secondary symptom caused by the viral infection. In this case, it is necessary to continue to use the original medication for continuous treatment, and there is no need to adjust the type of medication or the dose of medication. In the use of topical ointment for the treatment of skin diseases, if an adverse reaction occurs, you can first consult the doctor’s advice, under the guidance of the doctor to adjust the medication.