Recently, several cases of laparoscopic local excision of pancreatic tumor and pancreatic caudal resection with preservation of the spleen were successfully performed. Here we share a case of laparoscopic tail pancreatic resection with preservation of spleen (LSPDP). At first, we thought that it was difficult to perform spleen-preserving caudal pancreatic resection for this lesion, but the patient was very young and had a strong desire to preserve the spleen, so we agreed to try to preserve the spleen. After doing so, I felt that the whole process of lumpectomy to separate the splenic vessels, free the pancreas, and resection was relatively smooth. The spleen is the immune organ of the human body and plays an important role in maintaining normal blood cell levels and immune function. However, it is a difficult operation and requires a high level of skill for the surgeon. There are two main types of laparoscopic preservation of the spleen: the Kimura method, which preserves the splenic artery, and the Warshaw method, which removes the splenic artery and preserves the short gastric and left gastric omental vessels. the Warshaw method simplifies the procedure but has a higher incidence of postoperative splenic infarction. The safety of laparoscopic pancreatic caudal resection with preservation of the spleen has long been recognized in the field. The laparoscopic visualization of the operative area is clear, which is more advantageous than open spleen-preserving pancreatic caudal resection. Moreover, laparoscopy is less invasive and has faster recovery, which greatly reduces the patient’s hospital stay. For benign lesions in the distal part of the pancreas, laparoscopic spleen-preserving pancreatic caudal resection should be preferred.