Amikacin is dangerous to use for three months and is prone to drug side effects, especially ototoxicity. Amikacin is a third-generation aminoglycoside antibiotic that achieves its antibacterial effect by inhibiting the synthesis of bacterial proteins. amikacin is mainly used for serious infections caused by Pseudomonas aeruginosa, Escherichia coli, Aspergillus spp, Klebsiella spp, and Serratia spp. General gram-negative bacillus infections using amikacin course of treatment is not more than 10 days, but for drug-resistant tuberculosis infections, often need to be used for three months, it is easy to side effects, amikacin serious side effects is ototoxicity, the use of three months is very likely to have ear toxicity and other dangers, pay attention to the use of drugs during the period of rechecking the hearing. Amikacin adverse reactions include rash, drug-derived fever, headache, eosinophilia, arthralgia, anemia and hypotension, etc. The damage to kidney function is also great, and long-term use is not advocated. It is prohibited for use in patients who are allergic to amikacin, who have a history of allergy to aminoglycosides, or who have had severe toxic reactions. Amikacin needs to be used under the guidance of a doctor, follow the doctor’s instructions, do not blindly use the drug on your own, so as not to cause adverse consequences.