Bitter mouth can be seen in cholecystitis, but can also be seen in other diseases, so the cause needs to be specifically analyzed, can not be presumed. Patients with cholecystitis may have a bitter mouth due to poor bile excretion, but oral inflammation, gastrointestinal disorders, Helicobacter pylori infection, diabetes, kidney stones and other diseases can also lead to the emergence of this symptom. Therefore, bitter mouth is not always caused by cholecystitis. It should also be noted that in addition to bitter mouth, the common clinical manifestations of cholecystitis include pain and discomfort in the right upper abdomen, nausea, vomiting, and aversion to oil and grease. In conclusion, when the symptoms of bitter mouth should be timely medical treatment, under the guidance of the doctor, combined with other clinical manifestations, test results, etc. to accurately diagnose the cause, do not blindly judge, do not dispose of, in order to avoid adverse consequences.