In 1921, insulin was isolated from animals, and in less than two years, insulin had spread around the world. 23 years later, it won the Nobel Prize in Biology and Medicine. The invention of insulin made diabetics around the world rejoice! They thought that diabetes could be well controlled. After nearly a century, looking back on this journey, although it can effectively control blood sugar, but it seems that it is not as ideal as people expected at the beginning. Many diabetics complain that “the more you take insulin, the fatter you get!” Is this true? First of all, we need to look at the efficacy of diabetes. Insulin is the only protein-based hormone secreted by the beta cells of the pancreas that can lower blood sugar in the body. It is under the action of insulin that the sugar in the blood can enter the cells and provide energy for the body. Does insulin make you fatter the more you take it? The second point, we need to understand the conservation of energy, obese people’s blood sugar itself is high, in promoting the conversion of blood sugar will lead to fat. The growth of flesh is not due to insulin, but the patient will transfer more calories into the body. Patients with type 2 diabetes caused by obesity cannot rely solely on insulin to control blood sugar, and if caloric intake is not controlled, the patient will enter a vicious cycle. The end result is more and more insulin and more and more fat. For patients with type 2 diabetes caused by obesity, the real way to control blood sugar is to control weight and restore it to a normal level, and never have the idea that “if I eat more good food this time, it’s a big deal to take more insulin.