Tongue cancer is the most common oral cancer. According to the UICC classification, cancer of the anterior 2/3 of the tongue (tongue body) belongs to the category of oral cancer; while the posterior 1/3 of the tongue (tongue root) should belong to the category of oropharyngeal cancer. There are more men than women with tongue cancer, but in recent years, there is a trend of more women and younger age of incidence. Most of them are squamous carcinoma. Tongue cancer mostly occurs at the edge of the tongue, followed by the tip of the tongue and the back of the tongue. It is often ulcerative or infiltrative. It is generally more malignant, fast-growing and infiltrative, and often affects the tongue muscle, resulting in limited tongue movement. Sometimes difficulty in speaking, eating and swallowing occurs. Late stage tongue cancer can spread to the floor of the mouth and the mandible and fix the whole tongue; it can invade the palatoglossal arch and tonsils in the later development. If there is secondary infection or invasion of the tongue root, severe pain often occurs, and the pain can be reflected to the auriculotemporal region and the whole ipsilateral head and face. Early cervical lymph node metastasis often occurs in tongue cancer, and the metastasis rate is high because the tongue has rich lymphatic vessels and blood circulation, and the mechanical movement of the tongue is frequent, which are all factors contributing to the metastasis of tongue cancer. The cervical lymph node metastasis of tongue cancer is often on one side, such as those occurring on the back of the tongue or crossing the midline of the tongue body can metastasize to the contralateral cervical lymph nodes; those located on the lateral edge of the tongue mostly metastasize to the submandibular and deep cervical lymph nodes in the upper and middle groups; cancer of the tip of the tongue can metastasize to the subchin or directly to the deep cervical lymph nodes in the middle groups. In addition, tongue cancer can metastasize distantly, usually to the lungs. Treatment】Comprehensive therapy should be the main treatment. For early-stage tongue cancer cases, surgery is generally advocated for radical treatment, and stage I or stage II neck clearing surgery is performed on the neck, which can also be followed up closely. For advanced cases, a comprehensive treatment plan should be adopted. We advocate induction chemotherapy followed by surgery and postoperative radiotherapy. For tongue cancer affecting the floor of the mouth and the mandible, a combined tongue, mandible and cervical lymphadenectomy should be performed on one side, and if there is metastasis on the opposite side, bilateral cervical lymphadenectomy should be performed. Because of the high rate of cervical lymph node metastasis and early metastasis of tongue cancer, selective, suprascapular hyoid or functional cervical lymphadenectomy is generally recommended. Because clinically no enlarged lymph nodes are found, it does not mean no metastasis. At the same time, selective cervical lymphatic dissection has a higher cure rate than therapeutic cervical lymphatic dissection, but bilateral simultaneous selective radical cervical lymphatic dissection is generally not done. For small and well-differentiated tumors in the tip of the tongue, the dorsum of the tongue and the front 2/3 of the tongue margin, local surgical excision including some normal tissues or cryotherapy can be performed. To restore the function of the tongue, any tongue defect more than 1/2 should undergo one-stage tongue reconstruction. Chemotherapy can be used as an adjuvant treatment before and after surgery in advanced cases, and surgical resection can be performed after the tumor has shrunk. In addition, chemotherapy is also indicated for patients with distant metastases. Postoperative radiotherapy is indicated for cases with cervical lymphatic metastases or poorly differentiated primary foci and tumor invasion of neurovascularity.