Tongue cancer is the most common oral cancer. According to the statistics of the Ninth People’s Hospital of Shanghai Second Medical University, the number of tongue cancer cases (%) is the most common tongue cancer, and most of them occur in the middle/lateral margin of the tongue. Clinical manifestations of tongue cancer: Early tongue cancer can be manifested as ulcers, exophytic and infiltrative types, and in some cases, the first symptom is only tongue pain, which can sometimes be reflected to the temporal or ear area. The lymph node metastasis rate of tongue cancer is high, usually around %, and the most frequent metastasis sites are the deep upper cervical lymph nodes. Diagnosis of tongue cancer: Diagnosis of tongue cancer is generally easy but early tongue cancer, especially the invasive type, should be diagnosed by palpation, which is more important than visualization. Treatment of tongue cancer: 1. Treatment of primary foci Early highly differentiated tongue cancer can be treated by radiotherapy, surgery alone or cryotherapy Late stage tongue cancer should be treated by combination therapy according to different conditions Radiotherapy plus surgery or triple or quadruple therapy Radiotherapy: it can be used as preoperative and postoperative adjuvant therapy for advanced tongue cancer cases Surgical treatment: it is the main treatment for tongue cancer T cases can be directly sutured by wedge resection more than cm away from the lesion; T-T cases should have half tongue resection up to total tongue resection as an important organ of mastication and language Tongue defect/above should be reconstructed at the same time Chemotherapy: for advanced cases Pre-operative induction chemotherapy can be used to improve the survival rate of patients. Cryotherapy: Cryotherapy can be considered for TT tongue cancer. 2. treatment of metastases Because of the high metastasis rate of tongue cancer, selective cervical lymphatic dissection should be considered for all cases except T cases; therapeutic cervical lymphatic dissection should be performed for patients with positive clinical lymph nodes. Prognosis of tongue cancer: According to our data, the annual survival rate of surgery-based treatment is generally above %; T cases can reach above %.