Tongue cancer is the most common malignant tumor in oral cancer, and its treatment is mainly based on comprehensive treatment. In early stage, surgery is the main treatment, and in middle and late stage, tongue cancer treatment plan is based on comprehensive treatment: preoperative radiotherapy + surgical radical treatment + postoperative radiotherapy, chemotherapy + cryotherapy + chemotherapy, radiotherapy + photodynamic therapy + chemotherapy, etc. The main purpose of comprehensive treatment plan for tongue cancer is to prevent tumor recurrence and distant metastasis after surgery, which is the right direction to improve the survival rate and cure rate. Specific plans are as follows; radiotherapy, surgical resection and photodynamic therapy can be considered for early stage highly differentiated tongue cancer, the disadvantages of each are that the speaking and eating functions are affected after surgery, the after-effects of radiotherapy are dry mouth, sore throat and swallowing dysfunction, etc. Photodynamic therapy has the side effect of light allergy. Advanced tongue cancer should be treated with comprehensive treatment, but all of them are aimed at prolonging survival time and improving survival quality. Typical case – The patient was a 55-year-old male, diagnosed with a moderately differentiated squamous carcinoma of the right tongue with intolerable local pain, no lymph node metastasis was detected by enhanced CT and no distant metastasis was detected by corresponding examination. The patient refused surgery and radiotherapy. He requested minimally invasive treatment-photodynamic therapy (PDT). The patient found discomfort in the middle of the right side of the tongue for nearly half a year, and the diagnosis of squamous carcinoma was confirmed by pathological biopsy at a local hospital, which showed a localized fissure of the tumor with an extent of about 3cm×2cm and a depth of about 0.6cm (photo a). The tumor was diagnosed by fluorescence after 48 hours, and a brick-red fluorescence was seen in the tumor area (photo b). The tumor was then treated with 630 nm laser irradiation, and tumor necrosis was seen after treatment (photo c). The patient was discharged 4 days after treatment and returned to the hospital 3 months later for a follow-up examination, and the tumor was seen to have disappeared (photo d). Through minimally invasive treatment means and preserving the tongue body and controlling the tumor, the patient’s quality of survival is well guaranteed, so PDT is increasingly used in domestic and international clinical applications.