Postoperative chest tightness and pain of esophageal smooth muscle tumor is considered to be related to mental factors, lung infection, pulmonary atelectasis, esophageal perforation, etc., which can be treated with medication or surgery as prescribed by doctor. 1. Psychological factors: some postoperative patients with esophageal smooth muscle tumor may have chest tightness and pain when they are overly nervous and anxious. Generally, no special treatment is needed, and it will be relieved after adjusting the mentality. 2. Lung infection: lung infection can easily affect the ventilation function, which is manifested as chest tightness and pain. If it is clear that the bacterial infection is caused by, can follow the doctor’s instructions with penicillin, cefixime and other antibiotic treatment. Viral infections can be treated with antiviral drugs such as oseltamivir and zanamivir. Oxygen can also be prescribed to improve breathing. 3. Pulmonary atelectasis: those with postoperative pulmonary atelectasis need to take the prone position, and should also turn over and breathe deeply. Infection with penicillin, ampicillin and other antibiotics, tuberculosis pulmonary atelectasis need to be treated with isoniazid, rifampicin and other anti-tuberculosis drugs. If the obstruction is caused by blood clots and phlegm plugs, it is necessary to remove the blood clots and phlegm plugs through fiberoptic bronchoscopy, and apply thrombin and other hemostatic drugs. 4. Esophageal perforation: Conservative treatment can be used for mild esophageal perforation, such as placing mediastinal drainage, intravenous nutrition and applying effective antibiotics to control infection. For patients with serious condition, surgical treatment such as esophageal perforation repair and esophageal stenting is feasible. It is recommended that those with postoperative chest tightness and pain after esophageal smooth muscle tumor should be further examined in order to clarify the cause of the disease and then follow the doctor’s instructions.