If creatinine is still high after four months of dialysis, it should be chronic renal failure. Patients with chronic renal failure have basically lost their renal function, at this time, they need to undergo renal replacement therapy, in which dialysis can only partially improve the renal function, so the blood creatinine will still be high, and the blood creatinine can be restored to normal in successful kidney transplant patients. Renal replacement therapy includes hemodialysis, peritoneal dialysis and kidney transplantation. Hemodialysis and peritoneal dialysis have similar efficacy and each has its own advantages and disadvantages. However, dialysis therapy can only partially replace the excretory function of the kidney (the removal of small molecule solutes is only equivalent to 10%-15% of the normal kidney), and cannot replace the endocrine and metabolic function of the kidney, at this time, the patient’s blood creatinine is still high. Kidney transplantation is the best renal replacement therapy at present, successful kidney transplantation can restore normal renal function (including endocrine and metabolic function), after successful kidney transplantation, blood creatinine can be normalized. If the creatinine is still high after four months of dialysis, it is recommended to consult a regular hospital in time, complete the relevant examinations and follow the doctor’s instructions for standardized treatment.