Don’t easily pick a blister on the toe seam, because when a blister grows on the toe seam, the local skin stratum corneum, including the basal layer of cells under the blister, is weak and can easily become secondary to infection. So once picked, it may cause local fungal or bacterial secondary infection, resulting in redness and swelling of the foot and increased inflammation. Therefore, in this case, it is necessary to apply cold compresses with 3% boric acid solution or topical application of zinc oxide ointment, which can ensure the absorption of local blisters and reduction of exudate to a certain extent. You can also use some creams with antibiotics, such as trimethoprim cream, which can relieve or prevent local infections to a certain extent.