Women with hard lumps on one side of the outer lip can be seen in vestibular cysts, syphilis noma, vulvar cancer, etc. They should consult a doctor in time to clarify the cause of the disease and then treat the symptoms, such as large vestibular cysts should be incised in time. Vestibular cyst is due to the blockage of the vestibular gland duct, the gland cavity is swollen to form a cyst. If it is a hard lump mostly seen in large vestibular gland cysts, it should be incised and drained promptly. The hard chancre of syphilis is seen in syphilis stage I infection, which causes a subcutaneous metaplasia that manifests itself as hard nodules and ulcers, and is treated mainly with benzylpenicillin, or ceftriaxone can be used. Vulvar cancer can be seen in human papilloma virus infection, the treatment is mainly surgical resection, but also can be radiotherapy, such as carmustine, paclitaxel and so on. Women with hard lumps on one side of the external lips have various situations, no matter what the situation is, they should consult a doctor in time and standardize the use of medication under the guidance of the doctor. In daily life, you should pay attention to change and wash your underwear diligently, and strengthen exercise.