Renal failure is a systemic multi-system clinical syndrome, when chronic renal failure occurs, it can cause systemic multi-organ and multi-system complications, as follows: 1. Systemic electrolyte metabolism balance disorders, after the occurrence of chronic renal failure, there can be metabolic acidosis, hyperkalemia, high sodium, high chlorine and other phenomena; 2. If it involves the cardiovascular system, it can be hypertensive, heart failure and other cardiovascular system manifestations; 3. If the cardiovascular system is involved, hypertension, cardiac failure and other cardiovascular manifestations may occur; 3. If the respiratory system is involved, pulmonary edema and other manifestations may occur; 4. If the digestive system is involved, anorexia, loss of appetite, nausea, vomiting and other manifestations may occur; 5. If the skin is involved, the increase of metabolites in blood due to the increase of creatinine in the blood can lead to itching of the skin; 6. If the endocrine system is involved, it may lead to chronic disorders of calcium-phosphorus metabolism and bone disease caused by calcium-phosphorus metabolism disorders; 7. If it involves the nervous system, it can cause memory loss in mild cases, and nephrotic encephalopathy in severe cases; 8. If it involves the blood system, it can cause renal anemia. Therefore, chronic renal failure is a multi-organ and multi-system disease. In the daily treatment of chronic renal failure, it is necessary to focus on the management of chronic kidney disease. And when treating the primary disease, it is necessary to focus on the comprehensive treatment of multi-organ and multi-system.