Fever, progressive anemia, obvious bleeding tendency, bone and joint pain, etc. may occur when leukemia relapses. 1. Fever: When leukemia relapses, the immunity of the body becomes worse, and it is easy to be infected, causing fever. 2. Progressive anemia: when leukemia relapse occurs, leukemia cells proliferate again in large numbers, which leads to the inhibition of normal hematopoietic function of bone marrow and other hematopoietic tissues of the body, resulting in progressive anemia, dizziness, gradually worsening fatigue, pallor and other symptoms. 3. Obvious bleeding tendency: when leukemia relapses, it may be easy to bleed due to various reasons such as reduction of platelets, which may be manifested as bleeding from skin mucous membranes, bleeding from nasal cavity, bleeding from gums and so on. 4. Bone and joint pain: when leukemia relapse occurs, a large number of leukemia cells will occupy the bone marrow, resulting in greater pressure in the bone marrow cavity, which may lead to bone and joint pain. This kind of pain is more intense, and it is not easy to be relieved by using general painkillers such as ibuprofen, etc., and there is no redness or swelling on the surface of the skin. Therefore, after the treatment of leukemia, we must attach great importance to the above recurrence manifestations, so as to facilitate the emergence of symptoms in a timely manner to seek medical treatment, to avoid the deterioration of the progress of the disease. Drug treatment should be carried out under the guidance of physicians.