In addition to the many psychological factors associated with personality differences, is there a physiological basis for them? A recent paper published in the journal Nature provides a partial insight into the mystery. Scientists found that a protein called Neuropsin and its associated signaling pathway in the amygdala of the mouse brain regulate anxiety behavior in mice after stress: removing or inhibiting the protein and signaling pathway caused the mice to lose their response to the original stimulus that triggered the anxiety behavior; conversely, injecting the protein into the amygdala restored the anxiety behavior. These proteins are also found in human brain tissue, so scientists speculate that the different levels of response to anxiety may also be related. When the sensory system perceives a stressful event, the human brain evaluates the current stimulus and compares it to past experiences, and a series of stress hormones are released, corticosteroids being the most prominent. At the same time, the limbic system of the brain acts in coordination with corticosteroids to regulate the activity of the hypothalamic paraventricular nucleus and to influence emotions. The amygdala is the main part of brain tissue that generates, identifies and regulates emotions, is responsible for the assessment of emotional events and the production of memories related to fear, and is the target of the actions of many stress hormones and neurochemical mediators. Changes in the structure and function of the amygdala in response to stress lead to corresponding changes in mood, which have been confirmed by clinical and experimental data. Exploring the microscopic world of the amygdala will help us to explore the mechanisms of emotion generation and help us to avoid harmful emotions. However, the current behavioral and neuroscientific research on emotions such as anxiety is still at a relatively early stage. For the general public, the generalization of psychological stress phenomena and their patterns in psychology looks more practical. It is well known that excessive anxiety can have undesirable consequences; is it a good thing not to have an anxiety response at all in the face of stress? In fact, we can compare the stress response to a bow with an arrow on the string. When the stress (stressor) pulls the string, if the string does not generate tension (anxiety) at all or collapses due to excessive tension, the arrow will not fly very far anyway. To achieve the desired goal, all we have to do is keep our anxiety within a beneficial range so that the stress response gives us the efficiency we need to get the job done well and quickly. When faced with stress, the degree of anxiety depends on various factors such as cognitive level, social support, and individual characteristics. Controlling, reducing or overcoming anxiety should also start from these aspects. Younger children may be fearful of the sound of thunder, yet when they learn how lightning is generated, their previous tension is greatly reduced. This is a simple example of how cognitive level exerts an influence on psychological stress. When we have a better understanding of the stress or life event and a higher level of foresight about the nature, extent, and likelihood of what is going to happen, the anxiety caused by the stress or life event will then be reduced. In a few cases, it is also a good idea to turn to a counselor when general communication and confessions do not meet the needs, especially after certain extreme events such as major natural disasters, mass casualties, and professional psychological support is more helpful in relieving group anxiety. Individuals with the same level of cognition and similar social support may also experience different levels of anxiety in response to the same stressor, and these differences are explained in terms of individual characteristics. It has been observed that individuals have different emotional responses to stress due to differences in age, gender, culture, occupation, physical fitness, or personality temperament. So, in the case of personality, culture, occupation, temperament and other factors can not be changed in the short term, what are the effective ways to make us in the face of stress, encounter anxiety to unload the baggage, better performance? First, improve the level of cognition, commonly known as “face it”: face the pressure will reduce fear and anxiety, anxiety often comes from a negative view of the unknown, rational analysis will enable us to recognize the situation; second, self-referral and humor, that is, “laugh at it “: tell yourself that even the worst case is just that, moderate self-deprecation and exaggerated expression to relieve anxiety is quite effective; third, seek help from others, that is, “share it”: encouragement and comfort from friends and family can sometimes calm our emotions, so that we gain courage and strength. Fourth, temporarily turn your attention elsewhere or rest, i.e. “shift it”: throw yourself into the court, practice Tai Chi or do yoga, and if you can still sleep, go to sleep, you will find that the situation may be much better after waking up; finally, when all the above efforts have little effect, the shadow of anxiety is always difficult to get rid of and affects normal life When we can also turn to professionals and drugs, that is, “treat it”: excessive anxiety has entered the stage of neurosis, doctors will be targeted to help you.