Epidemiological data show that the incidence of digestive tract diseases is the highest among systemic diseases. There is a causal relationship between inflammation, ulcers and tumors, which are common diseases of the digestive tract. Malignant tumors of the GI tract occupy the third place in the whole body, and there is a trend of youthfulness. Due to the popularity of gastroscopy, the detection and better treatment of early tumors in the gastrointestinal tract are possible. Gastroscopy is the only best method to diagnose gastrointestinal diseases, and the endoscopist can observe the gastrointestinal tumors through gastroscopy in an unobstructed manner and find abnormalities in time. If necessary, histopathological examination is then performed to determine the nature of the lesion. In Japan, gastroscopy has been included as one of the routine medical examinations. British medical doctors recommend that men over 40 years of age should have a colonoscopy once a year. The health services provided by modern hospitals for patients should be humane, and painless and minimally invasive in examination and treatment is a trend. Painless gastroscopy is the appropriate application of sedation and anesthetics during gastroscopy treatment, so that the patient can complete the examination and treatment in a state similar to light sleep. The whole process is comfortable, painless and memory-free for the patient. Under the supervision of anesthesiologists or nurses, the gastroenterologists operate the microscopy in the same way as ordinary gastroscopy. The main indications for painless gastroscopy are: 1. those who voluntarily request painless gastroscopy; 2. those who have indications for gastroscopy but are afraid of general gastroscopy; 3. those who have difficulty completing routine gastroscopy due to severe vomiting or other reasons; 4. those who have other diseases that make gastroscopy very necessary, such as hypertension, angina pectoris, old myocardial infarction, history of epilepsy and pediatric or psychiatric diseases, etc. Those who cannot cooperate. The advantages of painless gastroscopy are mainly the following four aspects: 1, so that the patient’s whole body is relaxed, not nervous before the examination, safe during the examination, no discomfort, and recover quickly after the examination; 2, so that the doctor can carefully examine all parts of the stomach and make a more accurate diagnosis, and at the same time, can try to avoid possible damage to the digestive tract from the instruments when entering the mirror, which is conducive to the judgment and treatment of the disease; 3, to shorten the examination time 4.It helps to reduce complications caused by tension, fear and non-cooperation, such as cardiovascular system accidents, intestinal spasm, bleeding and perforation.