Note for painless gastroscopy and colonoscopy: 1. For those who wish to undergo painless gastroscopy, it is best to make an appointment by phone for reasonable arrangement. 2.For those who have heart disease, electrocardiogram may be required, and if necessary, go to the cardiology outpatient clinic for treatment. 3.For those who have combined respiratory system diseases, respiratory system examination may be required, and if necessary, go to the respiratory medicine clinic for further treatment. 4.Fast for 8 hours and abstain from drinking for more than 4 hours before the analgesia; empty the bladder and remove the movable dentures and jewelry before the examination. 5.For your safety, you need to be accompanied; sign the informed consent form for analgesia before operation. 6.Do not engage in high-risk operations such as driving on that day. Contraindications to painless gastroscopy and colonoscopy analgesia: 1. Patients suffering from serious heart, lung, brain and other important organ diseases; patients with poor physical condition and unable to tolerate analgesia. 2.Patients who are allergic to the anesthetic analgesic used. 3.Patients with gastric retention, pyloric obstruction and upper gastrointestinal hemorrhage. 4.Patients who are morbidly obese with significant respiratory system disorders. 5.Patients who have recently suffered from upper respiratory tract infection with significant fever, wheezing, nasal congestion and cough. 6.Those who do not want to receive analgesia by gastrointestinal endoscopy.