Sleeping at night leg soreness and swelling can not sleep consider muscle strain, lower extremity vascular valve closure insufficiency, venous thrombosis, lumbar intervertebral disc herniation compression of the nerve root and so on, for the cause of the application of blood circulation pain medication, swelling medication, anticoagulant drugs, painkillers and so on. 1. If it is caused by muscle strain, you can take blood-activating and pain-relieving medicines, such as Shujinhuibaoqi tablets or elongation capsules, and use safflower oil locally, with massage to relieve it. 2. Lower extremity vascular valve closure insufficiency caused by the daytime sedentary standing lower extremity blood reflux is not good, caused by blood stagnation can be taken orally to reduce the swelling of drugs, such as MaiZhiLing dispersible tablets. 3. If there is venous thrombosis in the lower limbs, you can use rivaroxaban anticoagulation therapy under the guidance of the doctor and elevate the lower limbs. 4. If the herniated lumbar disc compresses the nerve root and leads to leg pain and swelling, you need to sleep on a hard board bed, wear a waist cuff if necessary, and when the pain is severe, take non-steroidal anti-inflammatory drugs (e.g., ibuprofen) and nerve-nourishing drugs (e.g., methylcobalamin) orally to treat the pain. At night, the leg pain and swelling can not sleep, if it often occurs, you need to go to the hospital to clarify the specific cause of treatment. The use of medication should be in accordance with medical advice.