Infantile spasms are also known as WEST syndrome. The disease is characterized by frequent spastic seizures, specific high-amplitude dysrhythmic EEG patterns and regression of psychomotor development after the disease as its basic clinical features in infants with the disease before 1 year of age (with a peak in the postnatal period of 4-8 months). Spastic seizures are mainly flexion, extension and mixed, but mixed and flexion seizures are the most common. In typical flexion seizures, the infant is nodding and bending (or extending) the legs, and in extension seizures, the infant has a foot-arch recoil-like appearance. The spasms occur in bunches of several or dozens of consecutive seizures, with rapid movements, and may be accompanied by crying. The seizures are often aggravated during sleep and awakening periods. Treatment: 1, ACTH25U intramuscular injection QD, 4-6 weeks Prednisone PO 2 months to reduce the dose to stop; 2, clonidine 0.01-0.03mg/kg.d gradually increase the dose, the efficiency of 54% complete control, 25% seizure reduction, 20% ineffective; 3, valproic acid, dipropylacetic acid efficiency reported 50% (20-25mg/kg.d). 4, carbamazepine (induced exacerbation is more common), lamotrigine can also be selected. 5, other vitamin B6, brain activator (effective alone, intellectual recovery can be) partially effective. 6, ketogenic diet (at present, for infantile spasms, if several drugs do not work well, to promptly use ketogenic diet treatment) ketogenic diet for infantile spasms, the rate of complete control of up to 35%, often within a few days to see results, the current ketogenic diet for refractory epilepsy to more mature.