Infantile spasms was first named by American physician Gibbs et al. It was not until 1989 that it was defined as a new epilepsy syndrome, called West syndrome, in the International League Against Epilepsy classification of epilepsy and epilepsy syndromes. It is considered to be a symptomatic or cryptogenic epilepsy with asymmetric “highly dysrhythmic” EEG features in both hemispheres, and is generalized seizure epilepsy. There is a consensus to classify infantile spasms into two categories: symptomatic and idiopathic. The onset of infantile spasms ranges from 50% to 77% in the first 3-7 months of life, 93% before the age of 2 years, and about 2% after the age of 2. Some patients develop isolated, irregular bundle myoclonic seizures days to weeks after birth. 1, clinical manifestations: body axis spasms occur as the first form of seizures in infantile spasms, mostly on awakening. The spasm begins as a muscle contraction that lasts 0.5 to 2 seconds, followed by tonicity that generally lasts 10 seconds. The muscle contraction is often preceded by a scream, or laughter. The spasm may accumulate only in the neck, manifesting as a slight nodding of the head, or it may appear as an upraised upper limb or manifest as limited eye movements. Recurrent attacks in the same area are the main point of diagnosis. Myospastic manifestations are both flexion and extension spasms, which may alternate. Extensor spasms present as sudden neck and lower extremity end extension and upper arm extension inversion. Flexion spasms only show flexion of the neck and extremity ends, and inversion of the upper limbs in a shrimp-like manner. In 12% to 42.3% of patients, the presence of infantile spasms is preceded or accompanied by other types of epilepsy, including partial and generalized seizures. Intellectual, physical and mental developmental delays may also be present. EEG characteristics: The main changes during the seizure phase are: short-range low-frequency brain waves; multidirectional spike waves; diffuse slow waves or sharp slow waves; high amplitude bidirectional spike waves in the bilateral temporo-occipital region; and explosive high-amplitude atypical spike waves followed by short-range low-frequency fast rhythms. The typical EEG features of the interictal period are highly dysrhythmic. 3, 4/5 of infantile spasms may have positive findings on CT, MRI, evoked potentials, SPECT, PET, etc. Differentiation of infantile spasms from Lennox-Gastaut syndrome is difficult because many symptomatic infantile spasms evolve into Lennox-Gastaut syndrome, but the latter also has other seizure forms and a slow spike-slow or spike-wave EEG.