What are the risks of surgery for gastrointestinal mesenchymal tumors? The risks of surgery for gastrointestinal mesenchymal tumors are related to the age of the patient, the surgical procedure and the location of the tumor. Complications such as pancreatic fistula, bleeding, and anastomotic leak may occur after surgery for duodenal mesenchymal tumor; gastric mesenchymal tumor also has complications such as anastomotic leak and abdominal bleeding if it undergoes a major gastrectomy, but it has a lower incidence of fistula if it is only a wedge resection of the stomach. In conclusion, whenever patients undergo surgical treatment, they may face various complications, including bleeding and surgical infection. Can surgery cure gastrointestinal mesenchymal tumor? Surgery is the only way to cure gastrointestinal mesenchymal tumor. Cure is the goal of treatment, but since gastrointestinal mesenchymal tumor is a type of malignant tumor, recurrence can exist after surgery despite undergoing radical surgery. After surgery, doctors will determine the probability of recurrence of the tumor based on its size, location, nuclear division phase, and the presence of rupture. Very low-risk patients have a very high five- or ten-year survival rate of more than 90%, while high-risk patients have a very high five-year recurrence rate of more than 50%. Therefore, for high-risk patients, the goal of cure is difficult to achieve by surgery alone.