If the thickening and unevenness of liver echoes in hepatitis B is caused by acute hepatitis, it is possible to cure it through active treatment in time. However, if it is caused by cirrhosis, it is usually very difficult to cure. When the liver is infected by bacteria, viruses and other pathogenic factors or attacked by hepatitis, it is easy to lead to liver cell degeneration, necrosis, so that the liver is damaged, and in the examination of hepatitis B liver echogenic thickening and unevenness will appear. Patients with acute hepatitis should take liver-protecting drugs for liver-protecting treatment as early as possible as prescribed by the doctor, such as glutathione tablets and polyene phosphatidylcholine capsules. If it is viral hepatitis, antiviral drugs should be taken under the guidance of doctors for treatment, such as entecavir dispersible tablets, tenofovir disoproxil fumarate tablets, lamivudine tablets and so on. Most patients are able to achieve a cure, so it is possible to cure such patients with hepatitis B liver echogenicity thickening and unevenness. Cirrhosis of the liver is due to a certain cause of liver repeated injury, resulting in necrosis of liver cells, and nodular regeneration, fibrous hyperplasia, and ultimately the formation of cirrhosis of the liver. Cirrhosis is an irreversible damage to the liver and is the final stage of chronic liver disease, even after systematic treatment, it is very difficult to achieve a curable effect. Patients who have hepatitis B liver echogenicity thickening unevenly should go to the hospital to improve the relevant examination, and follow the doctor’s instructions for treatment.