The difference between endogenous and exogenous coagulation is a matter of expertise, and it differs in the following ways: 1. The speed of coagulation, endogenous coagulation occurs more slowly, starting only in about a few minutes. The exogenous coagulation is relatively fast, starting in about ten seconds. 2, the conditions under which it occurs are also different, endogenous coagulation is usually initiated in the case of vascular damage and intravascular coagulation, and exogenous coagulation is usually initiated in the case of tissue damage. 3, the distribution of coagulation factors is also different, endogenous coagulation exists in the blood, and exogenous coagulation factors exist in the blood and tissues. 4, the activation of their The factors that activate them are also different. The activating factor for endogenous coagulation is mainly the activation of coagulation factor Ⅻ by subendothelial collagen fibers and foreign bodies, while the exogenous one is the coagulation factor produced by tissue injury.5. The activation of coagulation factor X is also different. Coagulation factor X in the case of endogenous coagulation is activated by coagulation factor Ⅸ, and coagulation factor VIII complex as coagulation factor X, while the exogenous one is activated by coagulation factor III complex. 6. There are also different factors that are involved in different clotting factors. The main participants of endogenous clotting factors are clotting factor VIII, clotting factor IX, clotting factor D and clotting factor Ⅻ, and the exogenous ones are mainly involved in clotting factors III and VII. Coagulation factors are substances directly involved in blood clotting in plasma and tissues. 14 types of coagulation factors are known, among which coagulation factor D Ⅺ belongs to coagulation factor V, which is not an independent coagulation factor, and its essence is protein, but coagulation factor Ⅸ is calcium ion.