Peeling with retinoic acid cream may be a normal phenomenon, which can be relieved in 1 to 2 days; or it may be an adverse reaction to the drug, and its peeling persists, requiring discontinuation of the drug. Vitamin A cream, is a keratolytic drug, belongs to the western medicine. The main ingredient inside the drug is all-trans retinoic acid, the nature of the white to yellowish cream, mainly used for acne vulgaris, mucous membrane white spots, flat warts, hair erythema furfur, follicular keratosis and psoriasis adjuvant therapy. Some patients in the use of retinoic acid cream at the beginning of the burning sensation, erythema, peeling and other symptoms of irritation, if the individual skin tolerance is good, 1 to 2 days after this symptom can be relieved. There are also some patients with sensitive skin, can not tolerate such drugs, will continue to exist peeling and other symptoms, belong to the adverse effects of the drug, the need to stop the drug immediately, and will be cleaned up the local drug, if necessary, consult a physician. The drug is contraindicated in the first trimester of pregnancy, breastfeeding, allergy to any of the components of the drug, the eyes and other mucous membrane areas. It is forbidden to change the properties of the drug. If you are using other drugs, you need to consult a physician or pharmacist before using this product. In conclusion, the use of retinoic acid cream may cause adverse reactions leading to peeling, if the symptoms are obvious, it is recommended to go to the dermatology department of the hospital, and under the guidance of the doctor to change to other drugs for treatment.