Gastrointestinal mesenchymal tumors can be treated by medication, surgery, chemoradiation, etc., so as to control the disease and improve the prognosis. 1. Drug treatment: patients with gastrointestinal mesenchymal tumors can use targeted drugs, such as imatinib, sunitinib, regorafenib and so on, under the guidance of doctors, which can help to make those who can’t undergo surgery themselves have access to surgery, reduce the phenomenon of surgery and so on, and increase the chances of eradicating tumors and protect the structure and function of vital organs. 2. Surgical treatment: without contraindications to surgery, patients need to choose surgical treatment, such as laparoscopic surgical treatment, gastrointestinal endoscopic resection, open surgery and so on. Most patients can control the development of the disease and improve the prognosis after surgery. 3. Chemoradiotherapy: After the failure of conventional treatment, patients can take radiotherapy, so as to improve the quality of survival. Once diagnosed with gastrointestinal mesenchymal stromal tumor, patients should take into account their own situation and actively cooperate with the doctor’s guidance to take relevant treatment measures, so as to avoid affecting their health.