Alkaline phosphatase is a hydrolytic enzyme, the main role is to remove phosphate, alkaline phosphatase in the human body mainly exists in the liver, bile ducts, kidneys, bones and placenta, when the test found alkaline phosphatase is high, you can consider the following aspects of the cause: 1, physiological increase: children and adolescents in the bone development period, its alkaline phosphatase activity is much higher than normal, the test value will be higher than normal. The test value will be higher than normal; and the placenta contains alkaline phosphatase during pregnancy, the test result will also be high. All of the above are physiological increases and do not require treatment. 2, pathological increase: (1) skeletal factors: vitamin D deficiency leading to calcium deficiency osteoporosis; fractures, bone tumors, multiple myeloma, etc. may lead to high alkaline phosphatase. (2) Liver and biliary diseases: bile duct blockage, cholestasis, hepatitis, cirrhosis and liver tumors may lead to high indexes. (3) Primary hypothyroidism and primary hyperparathyroidism can lead to high alkaline phosphatase. 3, drug effects: certain drugs such as barbiturates, and antibiotics can cause an increase in alkaline phosphatase, which can return to normal after discontinuing the drug. Simple alkaline phosphatase increase, to consider the skeletal development period and pregnancy, it is recommended that we should also be alert to the pathological changes of bone, liver and gallbladder and kidney, comprehensive analysis of the causes and symptomatic treatment.