H. pylori positivity grade 3 three mainly refers to a H. pylori positive infection of 3+ and a strong correlation with gastritis and gastric ulcers. The level of H. pylori mainly indicates the degree of positivity of the infection, which is generally categorized into four levels, and the third level already indicates that the patient has a strong positivity, and at this time, it is necessary to eradicate H. pylori. At present, the commonly used medication to eradicate H. pylori is quadruple therapy, which mainly includes an acid inhibitor such as omeprazole, a gastric mucosal protector such as bismuth, and two antibiotics such as amoxicillin and levofloxacin, etc. All of the above medications should be taken under the supervision of a doctor. All of the above medications should be used regularly under the guidance of a doctor, avoiding self-medication.