Stage IVA of lung squamous carcinoma belongs to advanced stage, and patients with advanced lung squamous carcinoma should be treated with comprehensive treatment principle of systemic therapy, and individualized treatment strategies are formulated according to patients’ pathological types, molecular genetic characteristics and body status. It is mainly based on chemotherapy, supplemented by radiotherapy, interventional therapy and targeted therapy. 1. Patients with squamous lung cancer IV are not suitable for surgery, so drug chemotherapy can be applied to prolong the survival period of patients and improve the quality of life. Commonly used drugs are gemcitabine, paclitaxel, pemetrexed, etc., which can be combined with platinum drugs such as cisplatin and carboplatin. 2. Palliative radiotherapy can kill cancer cells through radiation, which can inhibit the development of lung tumor and relieve symptoms at the same time. 3. Interventional therapy for lung cancer, such as bronchial artery perfusion chemotherapy, which has little toxic side effects, can reduce the pain of patients with advanced squamous lung cancer.4. In addition, targeted therapies can improve the prognosis and prolong the survival time of some patients. The drugs include gefitinib, afatinib and so on. In addition, some patients can also receive immunotherapy and so on. Patients with stage IVA of squamous lung cancer should receive regular treatment in time, and the prognosis of the disease can be improved through early detection, early diagnosis and early treatment.