After 7 days of azithromycin treatment or slight discomfort in the urethra, it is not necessarily drug resistance. In order to diagnose whether there is drug resistance, need to do drug sensitivity test, if it is caused by bacterial infection should be treated with sensitive antibiotics; urethra feeling discomfort is not necessarily caused by bacterial infection, but also may be caused by fungi, tuberculosis, viruses, etc., need to do bacterial culture, do urine routine and other related tests. With azithromycin can produce gastrointestinal reactions, such as vomiting, nausea, abdominal distension, irregular bowel movements and other adverse reactions, allergies should be used with caution, to use azithromycin under the guidance of the physician face. After 7 days of azithromycin treatment, or slight urethral discomfort, need to do further examination, under the guidance of the physician face to face to choose the appropriate medication; patients should not self-medication.