Nail thickening inside the white residue, most of the fungal infection caused by nail fungus, you can through the topical drug therapy, systemic drug therapy to regulate. 1. Topical drug treatment: since topical drugs can’t easily penetrate the nail plate, you can first use a knife or nail file to remove the diseased nail as much as possible, and then use urea ointment for sealing and softening, so as to make the diseased nail softened and peeled off, and then apply antifungal drugs, such as cyclopiazepoxide ointment and amorphophallus nail applicator. 2. Systemic medication: patients with long duration of illness, recurrent attacks or those who do not have obvious effect of simple topical medication can consider oral itraconazole capsules, terbinafine tablets and other antifungal medications. It is recommended to go to the hospital for examination to clarify the cause of the disease, and the drugs need to be used under the guidance of a professional doctor.