Headache when patients look up may be caused by physiological factors such as insufficient sleep and work pressure, or it may be caused by pathological factors such as migraine and glaucoma. 1. Physiological factors: If the patient’s daily life is not regular, work pressure is too high, and the patient does not have enough sleep at night, the patient may have a headache when looking up, accompanied by dizziness and blurred vision. 2. Migraine: Migraine has a family genetic susceptibility, when migraine attacks, patients may have frequent headaches, and the symptoms will be significantly aggravated when the eyes look up. 3. Glaucoma: When the intraocular pressure of glaucoma patients increases, it may stimulate the peripheral nerves, thus causing headaches, and the symptoms will be aggravated when the eyes look upward, and it will cause eye swelling and pain, vision loss and other uncomfortable symptoms. Patients with significant eye pain are advised to seek medical attention to assess their condition and follow medical advice.