Tacrolimus treatment of membranous nephropathy for four months is not effective, you can continue to use the drug, but first need to clarify whether there is a combination of certain hidden complications, such as infection, venous embolism and other conditions that affect the efficacy of the drug.
Membranous nephropathy is prevalent in middle-aged and old-aged men, and the symptoms are mostly manifested as nephrotic syndrome, and has a high incidence of arteriovenous thrombosis. The prognosis is poorer if the patient has persistent proteinuria, advanced age, hypertension and fibrosis.
For patients with membranous nephropathy, according to the risk stratification, for patients with moderate risk, we can consider the use of immunosuppressants such as tacrolimus alone, the general treatment needs to be observed for half a year, if the efficacy of the treatment is not significant, we can consider replacing it with other medications; at the same time, for the patients with unsatisfactory results, we need to rule out the combination of infection, venous embolism, insufficient concentration of drugs and other conditions.
Membranous nephropathy patients are recommended to consult regular hospitals in time and follow the doctor’s instructions for standardized treatment. Adjustment of medication needs to follow the doctor’s instructions, do not self-medication.