Headache, leg pain, lumbar pain, generalized weakness, first of all, exclude whether there is osteoporosis. Osteoporosis will cause generalized soreness and weakness, generally the soreness is most obvious in the lumbar back, and severe osteoporosis will also cause pathologic fracture of vertebrae, mostly compression fracture of thoracic 12. In addition, if there is generalized pain and weakness, it is also necessary to exclude whether it is vitamin D deficiency. Vitamin D deficiency in adults can cause generalized weakness and lead to osteochondrosis in adults, with severe weakness and aches and pains, especially bone pain in the lower back and legs, twitching in the hands and feet, and muscle spasms.