Heterozygosity of chromosome 8 may be associated with couples, but it is not absolute, and there are many factors that affect chromosome 8 abnormalities. Chromosome 8 syndrome is caused by chromosome segregation errors during meiosis. If both parents have chromosomal abnormalities, it may lead to chromosome 8 abnormality in the fetus, or there may be mutations in the causative genes of recessive genetic disorders, which may lead to the occurrence of the corresponding diseases. In addition, fetal chromosome 8 trisomy may be caused by the mother’s early exposure to external toxic environmental influences or taking certain medications that lead to fetal gene mutation to form trisomy structure. Chromosome 8 trisomy may lead to mental retardation, peculiar facial features, obvious abnormalities of the toes, abnormalities of the ureter, acute myeloid leukemia, myeloproliferative disorders, joint spasms, etc., which need to be handled accordingly under the supervision of a doctor.