A low estradiol test can lead to the formation of empty follicles, but low estradiol is not the only cause of empty follicles. There are a number of reasons for empty follicles, or follicles without eggs, including low estradiol or low follicle stimulating hormone (FSTH), and in some cases, premature ovarian failure may also lead to empty follicles. If the ovarian follicles themselves are empty during the examination, and estradiol is also significantly low in the body, but other hormone levels are normal, you can first adjust the estradiol level in the body to see if you can achieve the goal of improving the empty follicles. Because if there is an empty follicle, there is no normal egg in the follicle, it is difficult to conceive normally in this situation, so you can first regulate it, according to the recovery of the body and then deal with it accordingly.