It is difficult to completely break the root of corns on the hands and easy to recur after cure. However, through general treatment, drug treatment, surgical treatment and physical therapy, the symptoms can be effectively improved to achieve the purpose of clinical cure. 1. General treatment: this disease is mainly caused by friction and extrusion of the hands, resulting in local skin cone keratosis. In daily life, the cause should be corrected in time to reduce the friction and extrusion of the hands. 2. Medication: patients can wash the affected area with warm water, soften the keratin, and then use topical corns cream, 50% salicylic acid ointment and other drugs for treatment. After the use of drugs, some patients may be localized burning sensation, skin rash and other adverse reactions, should be promptly discontinued to seek medical attention. 3. Surgery: For patients whose internal medicine treatment is ineffective, surgery can also be taken to remove corns. 4. Physical therapy: such as cryotherapy and laser therapy, etc., can be used in conjunction with other measures. This disease is difficult to cure, easy to recur characteristics, once diagnosed, should be timely medical treatment. Corresponding therapeutic measures must follow the doctor’s instructions.