Antinuclear antibody 1:320 is a positive result, suggesting that the patient may have a disease such as systemic lupus erythematosus, dry syndrome, rheumatoid arthritis, etc. The length of treatment varies according to the specific type of disease, the patient’s condition, and personal factors. Long-term treatment may be required. Antinuclear antibody is a general term for antibodies to nuclear proteins and anti-nucleic acids in the human body, and is an important marker for autoimmune diseases. Antinuclear antibody 1:320 suggests that the patient may have systemic lupus erythematosus, dry syndrome, rheumatoid arthritis and other diseases. Therefore, depending on the specific type of disease, patient’s condition, personal factors and other factors, the specific length of treatment varies greatly, and some autoimmune diseases such as SLE and rheumatoid arthritis may require long-term treatment. Laboratory reports need to be interpreted by a professional physician, and it is recommended that patients with 1:320 positive antinuclear antibodies go to the Department of Rheumatology and Immunology of a regular hospital for a detailed consultation on related matters.