There is a correlation between low gastrin-17 and the development of gastric cancer. Gastrin-17 is one of the four tests of gastric mucosa serum, which includes: pepsinogen 1, pepsinogen 2, gastrin-17 and anti-HpIgG antibody. Gastrin-17 is mainly produced by G cells in the gastric sinus. When HP infection is followed by destruction of G cells in the gastric sinus, it leads to a decrease in gastrin-17 secretion. Long-term chronic HP infection can lead to gastric atrophic gastritis, which is an important risk factor for precancerous gastric cancer. Therefore, low gastrin-17 has a certain relationship with the occurrence of gastric cancer, but it is only an indicator for screening, and the basis for the confirmation of gastric cancer is to rely on gastroscopic biopsy to find gastric cancer cells.