Blood glucose in mid-pregnancy may be higher than that in early pregnancy, but it may also be lower than that in early pregnancy, and there are certain individual differences. 1. Higher blood glucose in mid-pregnancy than in early pregnancy: In the middle and late stages of pregnancy, the antagonistic insulin-like substances (such as tumor necrosis factor and leptin) increase in the body of pregnant women; at this time, pregnant women’s sensitivity to insulin decreases with the increase of gestational weeks, and the insufficient compensatory secretion of insulin may easily lead to elevated blood glucose. Therefore, blood glucose in mid-pregnancy may be higher than that in early pregnancy. 2. Blood glucose in mid-pregnancy is lower than that in early pregnancy: In early and mid-pregnancy, the demand of the fetus for nutrients increases with the number of gestational weeks, and the main source of energy for the fetus is the glucose obtained from the mother through the placenta, which results in the lowering of blood glucose in pregnant women with the progression of pregnancy. As a result, blood glucose may be lower in mid-pregnancy than in early pregnancy. Elevated blood glucose or poor glycemic control during pregnancy has a significant impact on the pregnant woman and the fetus, and blood glucose should be actively controlled to prevent maternal and fetal complications.