Corticosteroids exert an inhibitory effect on the inflammatory response at different stages of allergic inflammation, reduce vascular permeability, attenuate the glandular response to cholinergic stimuli, and interfere with the metabolism of arachidonic acid (arachidonicacid), thereby reducing the production and release of mediators, inhibiting the production of cytokines (mainly interleukins 4,5,13), and inhibiting eosinophil granulocyte and basophil chemotaxis and migration to the nasal mucosa. Steroids can be administered systemically or topically for the treatment of allergic rhinitis, usually orally, and locally, mainly by nasal spray or, in rare cases, by submucosal injection. Generally speaking, the chance of needing systemic medication (oral) is less, only for acute, severe condition and patients with nasal polyps, oral prednisone 30-40 mg per day, once in the morning, for 7d or after symptom control, gradually reduce the dose, almost all patients are effective, but should avoid long-term medication, and pay attention to the occurrence of adverse reactions, generally speaking, the occurrence of adverse reactions is rare, because the medication time Generally speaking, adverse reactions are rare because the duration of use is not long and the dose is not high. However, occasional reports of mental excitement and acute osteonecrosis after several doses of the drug should be noted. Submucosal corticosteroid injections are rarely used, and long-acting or slow-release preparations can maintain the efficacy for several weeks in a single injection, and are suitable for hay fever, which can be injected once or twice during the onset of the season; continuous application is not recommended for patients with perennial allergic rhinitis. However, it may also cause retinal artery embolism and lead to blindness, so small molecule drugs should be used for injection, with a diameter of 6 μm or less, and the injection speed should not be too fast and the pressure should not be too high. Local application of steroids in the nasal cavity is a synthetic high-efficiency steroid drug, whose anti-inflammatory effect is hundreds to 10,000 times higher than that of hydrocortisone, and the drug is absorbed through the nasal mucosa and swallowed through the nasopharynx after the drug is used, and it is rapidly inactivated in the liver, which does not cause the side effect of adrenal cortical function inhibition, therefore, it is an effective and safe drug. There are various preparations and brands of steroid drugs for intranasal application, mainly: beclomethasone, flunisolide, budesonide and fluticasone, all of which have good therapeutic effects. The characteristic of these drugs is that they not only have obvious effect on nasal itching, runny nose and sneezing, but also have good effect on nasal blockage, and produce therapeutic effect 24 to 48 h after the drug is used, and the effect will be better with continued application. It has been reported that in the case of hay fever, topical nasal application of steroids can completely replace immunotherapy. For perennial allergic rhinitis with multiple allergens allergy, especially in patients with combined persistent cough and bronchial asthma, it is recommended that immunotherapy be applied simultaneously with this drug. Topical nasal side effects are rare, with occasional sensations of nasal dryness and bloody nasal secretions.