When aspirin is used to prevent thrombosis with antiplatelet aggregation, it should be used for a long time. For patients with indications for its use, such as hypertension, hyperlipidemia, diabetes mellitus, coronary artery disease, and obese patients, it can be used for primary prevention therapy. For women over 40 years of age and men over 50 years of age, low-dose aspirin can be used for thrombosis prevention if the incidence of cardiovascular disease in the next 10 years is between 6% and 10%. For patients with indications, long-term aspirin use should be maintained unless gastrointestinal bleeding, severe allergies, or liver damage occur during the course of aspirin use and aspirin has to be discontinued.