Sore throat after sleeping may be related to viral infection, bacterial infection or acid reflux stimulation, according to the situation to give targeted treatment. 1. Viral infection: when sleeping, if the organism is cooled by viral infection, resulting in acute upper respiratory tract infection, symptoms include sore throat, fatigue, low fever and so on. Symptoms such as mild symptoms can be treated symptomatically by drinking more water, resting more, and combining with tablets and mouthwash. Viral infections are mostly self-limiting. 2. Bacterial infection: If the pain symptoms further aggravate, accompanied by fever and other symptoms, it is considered that there may be a combination of bacterial infection. It is recommended to improve the blood routine and other tests, and give antibiotic anti-infection symptomatic treatment. 3. Stimulation of acid reflux: Acid reflux is also a common factor leading to sore throat. It is recommended that you sleep with a high pillow, do not eat before going to bed, and avoid eating too much. You can cooperate with the inhibition of gastric acid, promote gastric power drug symptomatic treatment. If you have a sore throat after sleeping, it is recommended that you go to the ENT department to clarify the cause of the disease and target treatment.