Compared with nephrotic syndrome, chronic nephritis and nephrotic syndrome are generally more serious, but it is also necessary to determine the current severity of the two diseases based on clinical symptoms and examinations, both have mild and severe disease, these two diseases can not be used to assess the severity of the disease, nor can they be used to predict the final outcome of the patient. The clinical symptoms of chronic nephritis and nephrotic syndrome are different. Chronic nephritis mainly includes clinical manifestations of hematuria, proteinuria, hypertension and edema. On the other hand, the symptoms of nephrotic syndrome mainly include a large amount of proteinuria, and there are hypoalbuminemia, edema, and hyperlipidemia, so generally speaking the clinical symptoms of proteinuria are more severe, and the degree of edema is more severe. In addition, although both diseases have hematuria symptoms. However, chronic nephritis is mainly due to inflammation caused by bacterial infection, which can be basically recovered through appropriate drug treatment, while nephrotic syndrome is generally due to lesions in the kidney area caused by other diseases. In summary, nephrotic syndrome is generally more serious, but some more serious types of pathology, such as focal segmental glomerulosclerosis can be manifested as nephritis, and patients with nephritis are more often accompanied by high blood pressure, which is one of the factors of the poor prognosis of nephropathy. Whether chronic nephritis or nephrotic syndrome patients are recommended to go to the hospital in time, under the guidance of the doctor for treatment.