Sudden nipple tingling may be caused by endocrine disorders, breast diseases, external stimuli, etc. Endocrine disorders are mainly manifested by pain around women’s periods, which is due to a substantial increase in the secretion of hormones in the body during menstruation, resulting in pain in the breast and nipple area, and some people may experience nipple tingling symptoms. Breast diseases such as breast enlargement, nipple tumor and breast cancer can cause discomfort in the nipples, often manifesting as nipple tingling, breast swelling and nipple overflow. Patients with mastopexy and breast cancer will have lumps in the breast, and patients with papilloma can observe localized raised sarcomas in the breast with the naked eye. External irritation is often caused by stabbing with sharp objects in intimate clothing or repeated irritation of the nipple skin by tight bras, resulting in sudden nipple tingling with slight bleeding.