High-grade intraepithelial neoplasia of the stomach generally refers to high-grade intraepithelial neoplasia of the stomach glandular epithelium, which can be cured by surgical resection under normal circumstances. High-grade intraepithelial neoplasia of the gastric adenoepithelium does not belong to cancer, but the presence of high-grade intraepithelial neoplasia may be a sign of precancerous lesions, and the possibility of cancer cannot be completely ruled out. Tumors that are not yet cancerous or have not yet spread can be cured by surgical removal in most cases. However, it should be noted that if this condition is not treated in time, it is very likely to turn into gastric cancer in the later stage, and after it turns into gastric cancer, the treatment is more complicated and the possibility of complete cure is relatively lower. It is recommended that patients with high-grade intraepithelial neoplasia should be treated by surgical resection under the guidance of doctors in time. It is suggested that patients should pay attention to it and receive treatment in the hospital as soon as possible, so as not to develop into more serious diseases such as gastric cancer.