Lysosome means the organelles in the cell that can decompose proteins, nucleic acids, polysaccharides and other macromolecules. Lysosomes contain a variety of hydrolytic enzymes, is one of the important structures involved in cellular metabolism, its main function is to participate in a variety of intracellular digestive activities, phagocytosis of pathogenic microorganisms, and lysosomal structural or functional changes in the diseases closely related to the silicosis, gout, congenital lysosomal disease these three. 1. Silicosis: after inhaling silica dust in the lungs, silica powder is phagocytosed by lysosomes in the lung tissue cells, but lysosomal enzymes cannot decompose it, instead, it is able to destroy lysosomes, leading to the release of hydrolytic enzymes inside, triggering cell death, and so on, triggering a domino effect, and causing great destruction of the lung tissues. 2. Gout: Uric acid crystals deposited in the periosteal cavity and connective tissue trigger inflammation, producing rheumatoid factor phagocytosis by cells, prompting the release of some lysosomal enzymes, further damaging the joints. 3. Congenital lysosomal diseases: the most typical of which is mucopolysaccharide deposition disease, due to the lack of lysosomes and metabolic disorders caused by genetic diseases, patients are often manifested as a rough face, bone abnormalities, mental retardation, in the heart, liver, spleen and other organs appear glycosaminoglycan deposition. It is recommended that patients with the above conditions go to regular hospitals for timely consultation and standardized treatment under the guidance of doctors to avoid delays.