Endoscopic treatment Includes endoscopic esophageal microfrequency treatment, endoscopic endoluminal gastroplasty, and total lamellar folding. Endo-luminal gastroplasty (ELGP) for GERD treatment involves mounting a suture at the front of the gastroscope and suturing the stomach wall tissue near the dentate line to form a fold under direct vision, increasing the tension near the cardia so that the fold blocks reflux and exerts a therapeutic effect. Radiofrequency therapy for GERD treatment is a minimally invasive treatment under the microscope, which increases the thickness of the lower esophageal sphincter, inactivates the nerve endings, inactivates the vagal receptors, and contracts the collagen tissue, thus increasing the thickness of the lower esophageal sphincter and the pressure of the lower esophageal sphincter, reducing the transient lower esophageal sphincter relaxation, and preventing GERD. Esophageal microfrequency therapy technique has been applied to GERD abroad for several years. We first introduced the Stretta micro radiofrequency therapy instrument and performed radiofrequency therapy for GERD patients for the first time in China. Radiofrequency treatment operation method: intravenous induction of anesthesia, gastroscopic identification of the gastroesophageal junction, placement of the radiofrequency treatment catheter at the treatment site, application of radiofrequency treatment instrument multi-level, multi-point radiofrequency treatment. This technology brings more simple treatment for GERD patients, and has outstanding features such as safe and effective, easy operation and quick recovery. Surgery Some GERD patients have recurrent attacks and cannot stop medication, and even a few patients cannot relieve their symptoms after medication, especially those with esophageal hiatal hernia, for whom medication is difficult to be effective. For severe or persistent GERD, surgical or laparoscopic surgery was required in the past. The surgical approach is highly effective in the short term, with rapid symptom relief and approximately 90% relief of heartburn and regurgitation symptoms, but the long-term outcome is not yet satisfactory and is greatly influenced by surgical experience. Laparoscopic fundoplication is currently the preferred surgical treatment for GERD. For patients with respiratory symptoms, especially those with asthma-like attacks, appropriate bronchodilator drugs should be applied in addition to treatment of GERD, and β2, receptor blockers such as benztropine and betalactone should be prohibited when other asthma-causing factors are not excluded. Our department established the first GERD center in China, and introduced the first American Stretta micro radiofrequency therapy instrument in China. With advanced instruments and equipment such as Japanese electronic gastroscope and graphic system, Dutch 24-hour gastroesophageal pH monitor and Danish gastroesophageal dynamics detector, it is feasible to perform gastrointestinal dynamic pH monitoring, esophageal dynamics detection, gastroscopy and other examinations and esophageal micro radiofrequency treatment. Since its establishment, the center has successfully completed micro radiofrequency treatment or surgery for more than 2,000 patients with GERD, about 70% of whom have combined respiratory symptoms, with remarkable efficacy.