The top 10 disorders causing childhood dwarfism are: 1, growth hormone neurosecretion disorder (GHND); 2, somatic delay in puberty; 3, intrauterine growth retardation; 4, idiopathic dwarfism; 5, precocious puberty; 6, nutritional deficiency growth retardation; 7, Turner syndrome (TS); 8, growth hormone deficiency (including partial growth hormone deficiency); 9, primary Hypothyroidism; 10. Trisomy 21.
The etiology of the disease by age group is as follows: 1. For <6 years old, the main causes are nutritional deficiency growth retardation, intrauterine growth retardation, and trisomy 21; 2. hypothyroidism; 3. The etiology of 13-18 years old is mainly somatic delayed puberty, precocious puberty and GHND. According to the etiology: 1. Insufficient secretion of growth hormone. Commonly pituitary or hypothalamic dysplasia or occupancy (tumor), or idiopathic growth hormone deficiency; 2. Defective synthesis of insulin-like growth factor or insensitivity to it; 3. Growth hormone insensitivity or resistance syndrome; 4. Intrauterine dysplasia. This is manifested by birth weight and/or length that does not correspond to gestational age; 5. Long-term chronic diseases that cause short stature, such as severe heart disease, chronic diarrhea, intractable nephrotic syndrome; 6. Certain congenital genetic metabolic diseases, such as Turner syndrome, trisomy 21, McCune-Albright syndrome, congenital chondrodysplasia, etc.; 7. Psychosomatic diseases, such as family discord and excessive 8.Familial genetic short stature; 9.Long-term untreated congenital hypothyroidism; 10.Physical delay in puberty (usually referred to as late growth).